|
KMID : 0829320130160040182
|
|
Korean Journal of Clinical Microbiology
2013 Volume.16 No. 4 p.182 ~ p.187
|
|
|
Antimicrobial Resistance and Molecular Epidemiologic Characteristics of Neisseria gonorrhoeae Isolated from Korea in 2013
|
|
Kim Hyo-Jin
Seo Young-Hee
Kim Wan-Hee
Lee Yang-Soon
Lee Hyuk-Min
Lee Kyung-Won
Chong Yun-Sop
|
|
|
Abstract
|
|
|
Background: Antimicrobial resistance of Neisseria gonorrhoeae has become a serious problem worldwide, and ceftriaxone non-susceptible isolates have been recently reported from Japan and Europe. In this study, we evaluated the antimicrobial susceptibilities and molecular epidemiological characteristics of isolates from Korea in 2013.
Methods: Sixty strains of N. gonorrhoeae were collected from Korean patients and prostitutes. Antimicrobial susceptibility was tested by the agar dilution and disk diffusion methods. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was performed in order to determine the molecular epidemiologic relatedness.
Results: All of isolates were non-susceptible to penicillin G and tetracycline, and the rate of ciprofloxacinresistant isolates was 95% in 2013. The MICs of ceftriaxone were within the susceptible range for all isolates, but one isolate non-susceptible to cefixime (MIC=0.5 μg/mL) was encountered. The isolates with decreased susceptibility (MIC≤0.12 μg/mL) to cefixime or ceftriaxone accounted for 10% and 14% of the isolates tested, respectively. In NG-MAST analysis, 40 different STs were encountered among the 59 isolates. Isolates that belonged to tbpB110 showed higher cefixime and ceftriaxone MICs (0.12-0.5 μg/mL) as well as cefixime resistance.
Conclusion: Most of the N. gonorrhoeae isolates showed susceptibility to spectinomycin and cephalosporins. Due to the emergence of isolates that are non-susceptible to cefixime and the prevalence of isolates with the tbpB110 allele belonging to ST1407, which cause cefixime and ceftriaxone treatment failure in successful global clones of N. gonorrhoeae, a continuous nationwide antimicrobial surveillance program is required to monitor the emergence of cephalosporin resistance in N. gonorrhoeae.
|
|
|
KEYWORD
|
|
|
Microbial sensitivity tests, Neisseria gonorrhoeae, Neisseria gonorrhoeae multiantigen sequence typing
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|